Prevalence of Thrombocytopenia in Dengue Fever Patients

Nida Tabassum Khan; Shabbir  Hussain

doi:10.54518/rh.1.6.2021.254-262

Authors

Nida Tabassum Khan Balochistan University of Information Technology, Engineering and Management Sciences, Pakistan
Shabbir Hussain Balochistan University of Information Technology, Engineering and Management Sciences, Pakistan

DOI:

https://doi.org/10.54518/rh.1.6.2021.254-262

Keywords:

Thrombocytopenia, Non-haemorrhagic complications, Platelets, Dengue

Abstract

Dengue fever (DF) is an intense febrile disease described by abrupt beginning of fever of 3-5 days, intense migraine, myalgia, joint pain, retro-orbital agony, anorexia, gastrointestinal unsettling influences and different levels of thrombocytopenia. Thrombocytopenia has reliably been one of the likely clinical pointers of dengue severity. As our studies revealed that overall prevalence of thrombocytopenia in Dengue is high i.e., 69% from mild to severe. However, since the female to male ratio i.e., 21:79 was unfairly very low to generalize the gender-wise prevalence result. In addition, severity of clinical manifestation of dengue disease were correlated with the respective platelet counts and there was a negative correlation between platelet count and clinical complications indicating that lower the platelet count more are the complications and their respective severity as patients with lower platelet count was found to have higher chances of non-hemorrhagic complications. Further forthcoming investigations are expected to assess the utility of other blood indices in dengue fever so, there is a need to concentrate on the detail hematology profile and comprehend its significance so that the adverse outcomes of this rapidly spreading disease can be controlled to a great extent.

References

Aroor, A. R., Saya, R. P., Sharma, A., Venkatesh, A., & Alva, R. (2015). Clinical manifestations and predictors of thrombocytopenia in hospitalized adults with dengue fever. North American Journal of Medical Sciences, 7(12), 547.

Azeredo, E. L., Monteiro, R. Q., & de-Oliveira Pinto, L. M. (2015). Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediators of inflammation, 2015, 313842. https://doi.org/10.1155/2015/313842

Boo, Y. L., Lim, S. Y., P'ng, H. S., Liam, C. C. K., & Huan, N. C. (2019). Persistent thrombocytopenia following dengue fever: What should we do?. Malaysian family physician: the official journal of the Academy of Family Physicians of Malaysia, 14(3), 71.

Effler, P. V., Pang, L., Kitsutani, P., Vorndam, V., Nakata, M., Ayers, T., ... & Hawaii Dengue Outbreak Investigation Team. (2005). Dengue fever, hawaii, 2001–2002. Emerging infectious diseases, 11(5), 742.

Garcia, S., Morales, R., & Hunter, R. F. (1995). Dengue fever with thrombocytopenia: studies towards defining vulnerability of bleeding. Boletín de la Asociación Médica de Puerto Rico, 87(1-2), 2-7.

Guzman, M. G., & Harris, E. (2015). Dengue. The Lancet, 385(9966), 453-465.

Halsey, E. S., Marks, M. A., Gotuzzo, E., Fiestas, V., Suarez, L., Vargas, J., Aguayo, N., Madrid, C., Vimos, C., Kochel, T. J., & Laguna-Torres, V. A. (2012). Correlation of serotype-specific dengue virus infection with clinical manifestations. PLoS neglected tropical diseases, 6(5), e1638. https://doi.org/10.1371/journal.pntd.0001638

Halstead, S. B. (2007). Dengue. The lancet, 370(9599), 1644-1652.

Jayanthi, H. K., & Tulasi, S. K. (2016). Correlation study between platelet count, leukocyte count, nonhemorrhagic complications, and duration of hospital stay in dengue fever with thrombocytopenia. Journal of family medicine and primary care, 5(1), 120.

Khare, R. K., & Raj, P. (2017). Dengue Fever With Thrombocytopenia and It's Complications: A Hospital Based Study. Journal of Advanced Medical and Dental Sciences Research, 5(3), 72.

Kohli, U., Saharan, S., Lodha, R., & Kabra, S. K. (2008). Persistent thrombocytopenia following dengue shock syndrome. The Indian Journal of Pediatrics, 75(1), 82-83.

Mehboob, R., Munir, M., Azeem, A., Naeem, S., Tariq, M. A., & Ahmad, F. J. (2013). Low platelet count associated with dengue hemorrhagic fever. International Journal of Advances in Chemistry (IJAC), 1(1), 29-34.

Mukker, P., & Kiran, S. (2018). Platelet indices evaluation in patients with dengue fever. Int J Res Med Sci, 6(6), 2054.

Nelson, E. R., & Bierman, H. R. (1964). Dengue fever: a thrombocytopenic disease?. Jama, 190(2), 99-103.

Nugent, D., McMillan, R., Nichol, J. L., & Slichter, S. J. (2009). Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production. British journal of haematology, 146(6), 585-596.

Ojha, A., Nandi, D., Batra, H., Singhal, R., Annarapu, G. K., Bhattacharyya, S., ... & Guchhait, P. (2017). Platelet activation determines the severity of thrombocytopenia in dengue infection. Scientific reports, 7(1), 1-10.

Raikar, S. R., Kamdar, P. K., & Dabhi, A. S. (2013). Clinical and Laboratory Evaluation of Patients with Fever with Thrombocytopenia.

Schexneider, K. I., & Reedy, E. A. (2005). Thrombocytopenia in dengue fever. Current hematology reports, 4(2), 145-148.

Selvan, T., Souza, J. L. D., Giridhar, N. S., & Kumar, M. (2015). Prevalence and severity of Thrombocytopenia in Dengue fever in children. Scholars journal of Applied Medical Sciences (SJAMS), 3(5D), 2068-70.

Wiwanitkit, V. (2010). Dengue fever: diagnosis and treatment. Expert review of anti-infective therapy, 8(7), 841-845.